José A. Prieto

José A. PrietoProfessor

Office: Facundo Bueso Building, FB-111
Telephone:  787-787-759-6880, Fax 787-759-6885
Laboratory: Facundo Bueso Building, FB-104
Lab Phone: 787-764-0000, ext 4809

Lab Home Page:




PhD: Universuty of Puerto Rico
Postdoc: University of California at Berkeley

Research Interests

Organic and organometallic synthesis, Lewis acid catalysis, new methodologies for the synthesis of biologically active compounds, chiral synthesis of polypropionates based on oxirane chemistry

Selected Recent Publications

"Stereoselective construction of all-anti polypropionate modules: Synthesis of the C5-C10 fragment of streptovaricin U", Torres, Wildeliz; Rodriguez, Raul; Prieto, José J. Org. Chem. 2009, 74, 2447–2451. (doi: 10.1021/jo8026966)

"Regioselective Cleavage of 3,4-Epoxy Alcohols with Substituted Alkynylaluminum Reagents: Application to the Stereoselective Synthesis of Polypropionates" Dávila, W.; Torres, W.; Prieto, J. A. Tetrahedron 2007, 67, 8218-8226. (doi:10.1016/j.tet.2007.05.122)

"Highly Regioselective Copper Catalyzed cis- and trans-1-Propenyl Grignard Cleavage of Hindered Epoxides. Application in Propionate Synthesis", Rodríguez, D.; Mulero, M.; Prieto, J. A.* J. Org. Chem. 2006, 71, 5826-5829. (doi: 10.1021/jo060833t)

"Regioselective Cleavage of cis- and trans-2-Methyl-3,4-Epoxy Alcohols with Diethylpropynyl Aluminum", Tirado, R.; Torres, G.; Torres, W.; Prieto, J. A.* Tetrahedron Lett. 2005, 46, 797-801. (doi:10.1016/j.tetlet.2004.12.018)

"Microwave-assisted epoxidation of hindered homoallylic alcohols using VO(acac)2: Application to polypropionate synthesis", Torres, G.; Torres, W.; and Prieto, J. A.* Tetrahedron 2004, 60, 10245-10251. (doi:10.1016/j.tet.2004.08.095)

"Efficient Hydroxyl Inversion in Polypropionates via Cesium Carboxylates", Arbelo, D. O.; Castro-Rosario, L. and Prieto, J. A.* Synthetic Commun. 2003, 33, 3211-3223. (doi: 10.1081/SCC-120023443)

“Using Molecular Modeling in the in the Organic Chemistry Course for Majors”, Montes, I.; Prieto, J. A.; García, M. The Chemical Educator 2002, 7, 293-296. (doi 10.1333/s00897020593a)

"Cesium propionate as an epoxide cleavage and inversion reagent", Arbelo, D. O.; and Prieto, J. A. Tetrahedron Lett. 2002, 43, 4111-4114. (doi:10.1016/S0040-4039(02)00739-6)

"Synthesis of Functionalized Enamines from Lithium Alkyl Phenyl Sulfones and N-Carbo-tert-Butoxy Lactams" Arias, L. Arbelo, D. Alzérreca, A. and Prieto, José A. J. Heterocyclic Chem. 2001, 38, 29-33.