Marvin Bayro

Marvin BayroAssistant Professor

Molecular Sciences Research Building
E-mail: marvin.bayro@upr.edu
Phone: +1 (787) 523-5326 
Homepage: https://nmrvin.wordpress.com/

Education

Postdoctoral Fellow. National Institutes of Health. Bethesda, MD.
PhD in Physical Chemistry. Massachusetts Institute of Technology. Cambridge. MA.
BA in Chemistry and Physics. Rutgers University. New Brunswick, NJ.

Research Interests

- Biophysical Chemistry: protein structure and dynamics
- Solid-state NMR Spectroscopy: methodology and applications
- Structural Virology: understanding HIV particle formation
- Biomaterials: protein stability and interactions with nanocomposites

 

Main Techniques and Instrumentation

- Magic-angle spinning NMR spectroscopy. 700 MHz
- Solution NMR spectroscopy. 700 and 500 MHz
- Electron microscopy - Protein expression, purification, and assembly

Publications

21. Bayro MJ, Ganser-Pornillos B, Yeager M, Tycko R. “Helical conformation in the CA-SP1 junction of the immature HIV-1 lattice determined from solid-state NMR of virus-like particles.” J Am Chem Soc (2016) 138, 12029-12032.

20. Bayro MJ, Tycko R. “Structure of the dimerization interface in the mature HIV-1 capsid protein lattice from solid state NMR of tubular assemblies.” J Am Chem Soc (2016) 138, 8538-8546. Featured in JACS Highlights.

19. Lu JX, Bayro MJ, Tycko R. “Major variations in HIV-1 capsid assembly morphologies involve minor variations in molecular structures of structurally ordered protein segments” J Biol Chem (2016) 291, 13098-13112.

18. Bayro MJ, Chen B, Yau WM, Tycko R. “Structural variations accompanying tubular assembly of the HIV-1 capsid protein.” J Mol Biol (2014) 426, 1109-1127.

17. Debelouchina GT, Bayro MJ, Fitzpatrick AW, Ladizhansky V, Colvin MT, Caporinic MA, Jaroniec CP, Bajaj VS, Rosay M, MacPhee CE, Vendruscolo M, Maas WE, Dobson CM, Griffin RG. “Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy.” J Am Chem Soc (2013) 135, 19237-19247.

16. Fitzpatrick AWP, Debelouchina GT, Bayro MJ, Clare DK, Caporinic MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TPJ, Saibil HR, Vendruscolo M, Orlova EV, Griffin RG, Dobson CM. “Atomic structure and hierarchical assembly of a cross-β amyloid fibril.” Proc Natl Acad Sci USA (2013) 110, 10976-10981. Cited in the Protein Data Bank’s Molecule of the Month.

15. Bayro MJ, Daviso E, Belenky M, Griffin RG, Herzfeld J. “An Amyloid Organelle: Solid-state NMR evidence for cross-beta assembly of gas vesicles.” J Biol Chem (2012) 287, 3479-3484.

14. Bayro MJ, Debelouchina GT, Eddy MT, Birkett NR, MacPhee CE, Rosay M, Maas WE, Dobson CM, Griffin RG. “Intermolecular structure determination of amyloid fibrils with magic-angle spinning, dynamic nuclear polarization NMR spectroscopy.” J Am Chem Soc (2011) 133, 13967-13974.

13. Debelouchina GT, Platt GW, Bayro MJ, Radford SE, Griffin RG. “Intermolecular alignment in beta2-microglobulin amyloid fibrils.” J Am Chem Soc (2010) 132, 17077-17079.

12. Sivertsen AC, Bayro MJ, Belenky M, Griffin RG, Herzfeld J. “Solid-state NMR characterization of gas vesicle structure.” Biophys J (2010) 99, 1932-1939.

11. Bayro MJ, Maly T, Birkett NR, MacPhee CE, Dobson CM, Griffin RG. “High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: Backbone conformation and implications for protofilament assembly and structure.” Biochemistry (2010) 49, 7474-7484.

10. Debelouchina GT, Platt GW, Bayro MJ, Radford SE, Griffin RG. “Magic angle spinning NMR analysis of beta2-microglobulin amyloid fibrils in two distinct morphologies.” J Am Chem Soc (2010) 132, 10414-10423.

9. Debelouchina GT*, Bayro MJ*, van der Wel PCA, Caporini MA, Barnes AB, Rosay M, Maas WE, Griffin RG. “Dynamic nuclear polarization-enhanced solid-state NMR spectroscopy of GNNQQNY nanocrystals and amyloid fibrils.” Phys Chem Chem Phys (2010) 12, 5911-5919.

8. Bayro MJ, Maly T, Birkett NR, Dobson CM, Griffin RG. “Long-range correlations between aliphatic 13C nuclei in protein MAS NMR spectroscopy.” Angew Chem Int Ed (2009) 48, 5708-5710.

7. Bayro MJ, Huber M, Ramachandran R, Davenport TC, Meier BH, Ernst M, Griffin RG. “Dipolar truncation in magic-angle spinning NMR recoupling experiments.” J Chem Phys (2009) 130, 114506.

6. Sivertsen AC, Bayro MJ, Belenky M, Griffin RG, Herzfeld J. “Solid-state NMR evidence for inequivalent GvpA subunits in gas vesicles.” J Mol Biol (2009) 387, 1032-1039.

5. Lin J, Bayro MJ, Griffin RG, Khaneja N. “Dipolar recoupling in solid state NMR by phase alternating pulse sequences.” J Magn Reson (2009) 197, 145-152.

4. Bayro MJ, Ramachandran R, Caporini MA, Eddy MT, Griffin RG. “Radio frequency- driven recoupling at high magic-angle spinning frequencies: homonuclear recoupling sans heteronuclear decoupling.” J Chem Phys (2008) 128, 052321.

3. De Paëpe G, Bayro MJ, Lewandowski J, Griffin RG. “Broadband homonuclear correlation spectroscopy at high magnetic fields and MAS frequencies.” J Am Chem Soc (2006) 128, 1776

2. Baran MC, Moseley HN, Aramini JM, Bayro MJ, Monleon D, Locke JY, Montelione GT. “SPINS: a laboratory information management system for organizing and archiving intermediate and final results from NMR protein structure determinations.” Proteins (2006) 62, 843-851.

1. Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH. “Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot.” J Am Chem Soc (2003) 125, 12382-12383. Featured in C&E News.