Arthur D. Tinoco


Assistant Professor

Office: NCN-224
Phone: (787) 764-0000 ext. 4846


Ph.D. in Bioinorganic Chemistry from Yale University (2007)
-Advisor: Ann M. Valentine

Postdoc at Harvard University Department of Chemistry and Chemical Biology (2012)
-Advisor: Alan Saghatelian

Research interests

Bioinorganic Chemistry, Chemical Biology, Metals in Biology, Studying small molecule mimics of metal-based enzymes, Development of new drug design strategies for metal-based therapeutics, Peptide-based drug delivery systems, Mass spectrometry based ‘omics’ studies for elucidating the mechanism of action of therapeutics

Selected publications

Parks, T.B.; Whitener, M.; Reynolds, M.S., *Tinoco, A.D. “Toward the development of a peroxovanadium(V) 2,6-pyridinedimethanolate small molecule mimic of vanadium bromoperoxidase.” Manuscript in preparation.

Tinoco, A.D.;  Mitchell, A.; Lone, A.M.; Saghatelian, A. “Elucidating substance P regulation via peptidomics and chemical inhibition.” Manuscript in preparation.

*Tinoco, A.D.; Thomas, H.R.; Incarvito, C.D.; Saghatelian, A.; Valentine, A.M. “Cytotoxicity of a Ti(IV) complex is independent of serum proteins.” Proc. Natl. Acad. Sci., 2012, 109, 5016-5021

Tinoco, A.D. and Saghatelian, A. “Investigating endogenous peptides and peptidases using peptidomics.” Biochemistry, 2011, 50, 7447-7461.

Tinoco, A.D.; Kim, YG., Tagore, D.M.; Wiwczar, J.; Danial, N.N.; Saghatelian, A. “A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones.” Biochemistry, 2011, 50, 2213-2222.

Tinoco, A.D.; Tagore, D.M.; Saghatelian, A. “Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform.” J. Am. Chem. Soc., 2010, 132, 3819-3830.

Lone, A.M.; Nolte, W.M.; Tinoco, A.D.; Saghatelian, A. “Peptidomics of the prolyl peptidases.” AAPS J. 2010.

Siburt, C.J.P.; Lin, E.M.; Brandt, S.J. Tinoco, A.D.; Valentine, A.M.; Crumbliss, A.L. “Redox potentials of Ti(IV) and Fe(III) complexes provide insights into titanium biodistribution mechanisms.” J. Inorg. Biochem., 2010, 104, 1006-1009.

Tinoco, A.D.; Peterson, C.W.; Lucchese, B.; Doyle, R.P.; Valentine, A.M. “On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis.” Proc. Nat. Acad. Sci. 2008, 105, 3268-3273.

*Tinoco, A.D.; Eames, E.V.; Incarvito, C.D.; Valentine, A.M. “Hydrolytic metal with a hydrophobic periphery: Titanium(IV) complexes of naphthalene-2,3-diolate, and interactions with serum albumin.” Inorg. Chem., 2008, 47, 8380-8390.

* Denotes corresponding author.